Compared with normoxic culture, hypoxia significantly upregulated the expression of osteogenic markers, including RUNX2, OPN, COL1A1, and Osterix (Figure 5d)
Charles Puza, a board-certified dermatologist in both medical and cosmetic dermatology at New York Dermatology Group, is seeing more patients coming in with concerns about skin changes after starting GLP-1 medications

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ClinicalTrials.gov (2013)
Healthy lifestyle and a balanced diet are highly recommended