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Gradinaru D., Borsa C., Ionescu C., and Margina D., Advanced Oxidative and Glycoxidative Protein Damage Markers in the Elderly With Type 2 Diabetes, Journal of Proteomics 92 (2013): 313322, 10.1016/j.jprot.2013.03.034

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Direct data showcasing such synergy remains scarce, so more experiments are needed for careful evaluation of cell-culture models in controlled laboratory settings

But their high costs and limited insurance coverage have impeded many people from obtaining or staying on these treatments long-term (some users are also unable to tolerate the common gastrointestinal side effects they cause)