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Polymeric nanomaterials can be made highly thermo-responsive for local radiotherapy by varying the hydrophilic/ hydrophobic moieties ratio, for example poly(N-isopoprylacrylamide) (pNIPAAm) labelled with L-tyrosinamide or diethyltriaminepenta acetic acid [136], and delivery of docetaxel-loaded in biodegradable thermosensitive copolymer poly(N-isopropylacrylamide-co-acrylamide)-b-poly(DL-lactide) can be increased for the chemotherapeutic effects [137]

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