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Multiorgan Hypersensitivity Reactions Instruct patients that a fever associated with other organ system involvement (rash, lymphadenopathy, etc.) may be drug-related and should be reported to the physician immediately [seeWarnings and Precautions (5.12)]

Each additional receptor target appears to unlock additional efficacy

Moreover, the majority of these early non-responders (53-70%) fail to achieve clinically meaningful weight loss of 5% after six months of treatment

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