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A useful indication of the safety margin available for a drug is given by the therapeutic index (TI): Drugs such as diazepam have a TI of about 50 and it is difficult for even the most inept doctor to cause serious toxicity with diazepam

Lancet (2021) 397:183041

Plasma free-carnitine levels rise within minutes of an intravenous dose, and many patients report improved energy or reduced muscle fatigue within days to a few weeks once tissue stores are replenished

AP events were predominantly reported for unknown indications (53.8%) and T2DM (43.0%)

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