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276 Pathological prion instigates neuronal death, which in turn causes secondary astrocytic reactivity predominantly in the white matter, but the roles of reactive astroglia in prion diseases are poorly understood and hampered by the emerging complexity of astrocyte responses to prion induced pathologies

The samples with GT 1 and subtype not determined using Abbott RT-PCR, which were successfully subtyped using the Roche-NGS test, were scored as minor discordance in the final analysis

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