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Updated February 2026 Retatrutide vs Survodutide Two next-generation obesity drugs that both include glucagon agonism how the triple and dual agonist approaches compare

In newer phase 3 trials, researchers used doses like 2 mg, 4 mg, 6 mg, 9 mg, and 12 mg, still taken once a week and increased slowly over time

Better blood pressure management 41% of patients in the 8 mg groups and 30% in the 12 mg group were able to stop taking at least one antihypertensive medication after 48 weeks on retatrutide

The term incretin refers to hormones that are released after a meal and help attune insulin release to the food taken in

382 This contributes to maintaining muscle strength and reducing inflammation