Higher-potency formulations (semaglutide up to 2.4 mg and tirzepatide) were used, which may account for stronger weight effects compared to pediatric trials that employed lower doses
An elevated ferritin eliminated iron deficiency or occult bleeding, while a high lactate dehydrogenase and hyperbilirubinemia suggested hemolysis
Of these, three are predominantly localized in the plasma membrane (SLC7A11/GPX4, FSP1/CoQ10, and GCH1/BH4), while DHODH/CoQ10 primarily functions to eliminate mitochondrial lipid peroxidation (Kuhl et al., 2012)
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Because the mechanism is appetite-based rather than metabolically suppressive, muscle preservation tends to be strong when paired with adequate protein and resistance training, which matters for sustaining results