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Heres one which compared manic patients who were on olanzapine or risperidone plus an antimanic mood stabilizer, lithium or valproate, and asked how long should you stay on it

However, they do come with risk of side effects like headaches that you should be aware of

Endocrinology (2009) 150(4):161826

Metabolic Readiness and the Plateau Effect Plateaus in weight loss are normal and expected

So when patients come back and they say, Doc, when I started the drug, I used to feel like I had no cravings, and now everythings back. And the reason is we are so good at adapting as human beings, as evolution is done, and we are also so good at overcoming things like medications