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These new discoveries, together with the in-depth preclinical characterization of NAD + modulators and ongoing developments in their translation in humans, will open further avenues of study of this essential cofactor and its clinical therapeutic potential

For acute administration of MCT, triheptanoin, and C 8 -carnitine, the lipids were either gavaged as the oils (MCT, triheptanoin) or dissolved in saline (C 8 -carnitine)