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Notably, LPS-induced NF-B activation occurs in two phases: an early phase (0.5-2 hours after stimulation) driven by TLR4 signaling, and a late phase (8-12 hours after stimulation) sustained by cytokines such like TNF- and IL-1 generated during the early phase (81)

Washington DC: The National Academies Press

Many patients remain asymptomatic until advanced disease develops, making incidental diagnosis through imaging or elevated liver enzymes common during routine health assessments

Nature 423, 550555