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Abdul Y, Abdelsaid M, Li W, Webb RC, Sullivan JC, Dong G, et al

They naturally fluctuate throughout a 24-hour cycle, often dipping when we are most exposed to environmental stressors or when our internal repair mechanisms are working overtime

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Under homeostatic conditions, transient activation of NRF2 is cytoprotective, allowing for adaptation to various cell intrinsic (i.e., reactive oxygen species (ROS) generated by mitochondrial function) and extrinsic (i.e., xenobiotic) stressors (Kensler et al, 2007

Therefore, targeting the HIF signaling pathway and its regulated downstream gene expression has become a potential strategy for treating hypoxia-related diseases