glp-1 weight regain after stopping receptor agonists | Gustavo Monnerat posted on the topic Procedure Shows Promise for Sustained

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In rodent studies, Reta has been generally well tolerated, with side effects typically limited to those commonly seen with incretin-based therapies, such as transient gastrointestinal symptoms

It is currently undergoing clinical trials

In small proof-of-concept phase 2 randomized controlled trials (RCTs) in patients with biopsy-confirmed MASH, liraglutide at 1.8 mg/day for 48 weeks (201), semaglutide at 0.4 mg/day for 72 weeks (202), and tirzepatide at 15 mg/week for 52 weeks (203) have been reported to achieve placebo-corrected percentages of participants meeting the criteria for resolution of MASH without worsening fibrosis by 30% (P = 0.019), 42% (P 10%) may lead to diabetes remission (237)

According to prescribing information, injection sites include abdomen, thigh, or upper arm, rotated weekly to minimize injection site reactions