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HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion

Studies suggest that IGF-1 LR3 might activate key signaling pathways, including the phosphoinositide 3-kinase (PI3K)/Akt and mitogen-activated protein kinase (MAPK) cascades, both of which are central to cellular proliferation and survival

decreased levels of IL-10 and increased levels of IL-17 may exacerbate inflammation in a specific manner (130, 131)

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PMID: 91 McGarrahRWWhitePJ