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Human studies examining circulating METRNL levels have produced heterogeneous results, reflecting differences in metabolic state, physical activity, and assay methodology

This pocket is formed by residues in transmembrane helices 1 (TM1), 2 (TM2), 3 (TM3), and 7 (TM7), along with contributions from extracellular loop 2 (ECL2)

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Pharmacologic strategies to modulate or enhance the effects of insulin hold particular importance for combatting psychotropic-associated weight gain