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FHD-609, a BRD9 degrader, elicited Grade 4 QTc prolongation and syncope in Phase 1 trials, resulting in a clinical hold by the FDA [121]

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Using an assay that employs a first step of antibody-based immunoenrichment followed by quantification of peptide isoforms using mass spectrometry, Wang et al (129) detected increased plasma levels of SDF-1 [167] and decreased levels of SDF-1 [367] in C57BL/6 mice acutely treated with the DPP4 inhibitor MK-0626

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