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doi: 10.1016/j.tibs.2022.10.002 126 NunesPRMattioliSVSandrimVC

"And it's not because of any magic it's because these are natural substances that our bodies make and are familiar with, so that's what gives them this incredible safety profile." The FDA, however, has publicly stated that there is not enough evidence from human clinical trials on the safety or efficacy of these drugs

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(4) Metformin may enhance GLP-1 secretion through PEN2, a subunit of -secretase