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[1] Particularly, it may signal and attract fibroblastscells responsible for synthesizing collagen, elastin, and other proteins in the skins extracellular matrix, bones, and connective tissues

Benefitrisk trade-off Muscle loss: Tirzepatide reduced fat mass the most (25.7%) but was also associated with the greatest reduction in lean body mass (8.3%)

These can include: Nausea or vomiting Constipation or diarrhea Fatigue or reduced appetite Rapid fat loss may cause hanging skin on the face and body (e.g., Ozempic face) To minimize discomfort, providers usually start at a low dose and slowly increase it