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Synaptotagmin 1 (Syt1) is a calcium-binding protein that plays a critical role in both exocytosis and endocytosis of SVs 6 , and that has been used as key target for studying SV recycling 7

Side effects tend to be mild and dose-dependent -- injection site reactions, temporary water retention, and mild tingling or flushing

When glucose builds up in the bloodstream, it damages blood vessels and nerves throughout the body over time

Intraperitoneal injections of trimetazidine (25 mg/kg/day for 5 days) in rats before seizure induction prevented apoptosis of hippocampal neurons [138]

Additionally, oxidative DNA damage can activate p53 and other pro-apoptotic factors, thereby further promoting apoptosis 26