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Peer review Peer review information Communications Biology thanks the anonymous reviewers for their contribution to the peer review of this work

The first reaction is catalyzed by -glutamylcysteine synthetase, joining L-glutamate and L-cysteine into -glutamylcysteine

Alcohol & Smoking Both alcohol and cigarette smoke increases free radical production, leading to greater oxidative damage and a higher demand for glutathione

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PTPN22 increases the risk of vitiligo owing to its effect on protein tyrosine phosphatase, which plays a key role in signal transduction and controls the activity of the T-cell immune system