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The overall economics will also depend on the required dose and frequency of administration

We also discuss some of the potential clinical challenges with the use of these new therapies when approved

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Using a continuous assay, we determined K M s of recombinant Cr GPDH as 45 3 M for NADH and 820 127 M for DHAP, while k cat s were 147 10 and 248 36 s 1 , respectively ( Figure 2e-f , Table 1 )