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It is rich in polyphenols, cardenolides, triterpenoids, steroids, saponins, alkaloids, flavonoid polyphenols, and tannins (27, 28)

however, it is highly recommended to conduct a patch test prior to regular application of skincare products

Side Effects and the Copper Uglies Explained GHK-Cu has a strong safety profile in topical research, but a small subset of users experience a transient phase known as the copper uglies. A 2023 clinical safety review covering 12 studies and 512 participants reported that the most common side effects of topical GHK-Cu were transient and mild

Studies on osteoblastic cell behavior showed that Tb4 promotes both adhesion and proliferation of osteoblasts through focal adhesion signaling and ERK1/2 activation