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Nevertheless, excessive PEGylation can introduce unintended consequences, including increased protein adsorption, which may alter the biodistribution and pharmacokinetics of the nanomaterials

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One hypothesis for these observed differences is that biological sex influences gut microbial composition through hormone-regulated immune and metabolic pathways, with sex steroid hormones and sex-linked genetic factors shaping the immune environment and selectively supporting the growth of certain microbial taxa (Jaggar et al., 2020)