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Interestingly, TFAM and mtDNA form a self-regulatory positive feedback loop: TFAM knockout triggers mtDNA depletion, while reduced mtDNA copy numbers further promote TFAM degradation [54,55,56] (Table 1)

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Allerdings wurden in der Anti-Aging- und Regenerationsmedizin bereits mehrjhrige Anwendungen dokumentiert, insbesondere in den USA, ohne dass schwerwiegende Nebenwirkungen beobachtet wurden

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