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4 Nanoparticles regulate DCs DCs are specialized antigen-presenting cells that can capture the antigens released by tumor cells and present them to T cells in tumor-draining lymph nodes to produce tumor-specific cytotoxic T lymphocytes (CTLs) (97), besides DCs can also stimulate NK cells and B cells to activate humoral immunity (98), therefore, strategies that increase the number of DCs or promote their maturation can enhance anti-tumor immunity

The GIP receptor activation in both tirzepatide and retatrutide appears to contribute substantially to insulin sensitization in fat tissue, which may explain why both outperform semaglutide on this metric

Additionally, their flexible dosing allows for treatment adjustments, ensuring therapies are tailored to specific patient responses

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A potent oxidizing agent that can be made in cells is hydrogen peroxide, which can lead to more drastic and irreversible chemical modifications to the Cys side chains