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Receptor activation triggers a sharp pulse of growth hormone release from the anterior pituitary within 15 to 30 minutes of injection

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Pharmacokinetics in Preclinical Models Research in animal models has reported ipamorelin's plasma half-life to be relatively short, generally in the range of approximately two hours, a property that has practical implications for study design: this short half-life has made ipamorelin a useful tool for studying discrete GH pulse dynamics within controlled laboratory timelines, without prolonged receptor saturation confounding the measurement window

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