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Rationale for the Recommendation Semaglutide (Wegovy) was reviewed by CDEC in October 2022 for the indication as an adjunct to a reduced calorie diet and increased physical activity for chronic weight management in adult patients with an initial body mass index of 30 kg/m 2 or greater (obesity), or 27 kg/m 2 or greater (overweight) in the presence of at least 1 weight-related comorbidity such as hypertension, type 2 diabetes mellitus (T2DM), dyslipidemia, or obstructive sleep apnea and was not recommended for reimbursement

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Finally, a study involving 69 GD patients with hyperthyroidism lasting more than 6 months showed decreased levels of erythrocyte SOD and catalase activities compared with controls, with no difference in erythrocyte GPX and total antioxidant activities (28)

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