It says that conversation may cover adjusting treatment, switching to a different agent in the class, or reconsidering whether the therapy fits at all, and that a clinician is needed to separate medication-related headaches from other causes
Endocrinology 159 , 665675 (2018)
Talk with your healthcare professional if side effects persist or disrupt your day-to-day life
No treatment should be used if you or any family members have had medullary thyroid carcinoma (MTC), or if you have a condition known as Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
Additional tirzepatide safety concerns include risk of acute gallbladder disease (presenting as right upper quadrant pain, fever, or jaundice), acute kidney injury from dehydration (especially if severe gastrointestinal symptoms occur), and hypersensitivity reactions