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Western blotting and Biacore analysis confirmed that L2-Cmu binds to and inhibits IGF-1R activation by IGF-1 (Ki = 3.3 nM) and IGF-2 (Ki = 3.3 nM) (Fig

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In addition, glucagon has re-emerged as a significant contributor to glucose homeostasis and energy metabolism [7]

While current evidence suggests beneficial effects, the complex role of GIP in energy metabolism could potentially lead to unexpected consequences with extended exposure

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