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Semaglutide 2.4 mg reduced the rate of major adverse cardiovascular events (MACE: cardiovascular death, nonfatal myocardial infarction, nonfatal stroke) by 20% compared to placebo (HR 0.80

The overall metabolic, cardiovascular, and weight-related benefits of these medications are well-established and should be weighed carefully against manageable side effects

This usually stabilizes once your weight and caloric intake become more consistent

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