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Starting doses on the lower end (300mcg) and progressing slowly makes sense

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The Universal Anti-Oxidant Alpha Lipoic Acid (ALA) is a natural antioxidant and anti-inflammatory compound which works to alleviate pain, protect the brain, decrease the risk of cardiovascular disease, help with weight loss, improve diabetes, fight cancer, and assist in the treatment of several other health conditions

C10 has a weaker effect, while C8 and shorter fatty acids are unable to activate UPCs (83)