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SLC1A5 glutamine transporter is a target of MYC and mediates reduced mTORC1 signaling and increased fatty acid oxidation in long-lived Myc hypomorphic mice

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(4) mGPDH in the regulation of ferroptosis G3P metabolism supports ferroptosis defense in disease contexts In the first study identifying mGPDH as a ferroptosis regulator, metabolomic analyses revealed that treatment of cancer cells with GPX4 inhibitors led to a marked depletion of intracellular glycerol3phosphate (G3P) 99

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