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Prevalence of thyroid dysfunction in kidney disease Hypothyroidism is a relatively common endocrine disorder in the general population, 22,23 and it is defined by a serum thyrotropin (TSH) concentration above the upper limit of the reference range accompanied by a serum free T4 (FT4) concentration that is low (i.e., overt hypothyroidism) or within reference range (i.e., subclinical hypothyroidism)

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