It blew me away
In FLS, miR-34a-3p (193), miR-129-5p (202), miR-410-3p (207), miR-506 (208), miR-22 (213), miR-101-3p (216), miR-495 (217), miRNA-17-5p (218), miRNA-140-5p (219), miR-21 (223), miRNA-15a/16 (224), miR-9 (230), miR-20a (234), miR-145-5p (235), miR-365 (236), and miR-124a (238) overexpression significantly inhibit the proliferation and promote apoptosis by aiming different proteins or other targets
In mouse models of type 2 diabetes induced by a highfat diet and streptozotocin, 4 weeks of 5amino1mq injection reduced fasting blood glucose by 25%30%, increased insulin secretion by over 20%, and significantly decreased cell apoptosis
Den Besten G, Van Eunen K, Groen AK, Venema K, Reijngoud DJ, Bakker BM
This indicates that while higher doses may have some impact on kidney function, this effect is reversible and does not occur at lower, more commonly used doses