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A note on supplements: The products included in this article are dietary supplements

Methotrexate demonstrates proven efficacy in reducing inflammation, slowing radiographic progression, and improving functional outcomes

The proportionally larger metabolic boost from glucagon activation narrows the baseline metabolic gap between sexes

Tirzepatide is a medication initially used for type 2 diabetes treatment that also demonstrates efficacy for weight loss and significant potential in reducing cardiovascular risks

Kidney problems: Ongoing dehydration from vomiting, diarrhea, or nausea can lead to a decline in kidney function