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The themes below summarise how these compounds are discussed in those spaces

Unlike sodium-glucose cotransporter-2 (SGLT-2) inhibitors a separate class of diabetes medication associated with an increased risk of genital mycotic infections (such as thrush) and, to a lesser and more variable extent depending on the individual agent, urinary tract infections retatrutide does not act on the kidneys in a way that would be expected to directly predispose individuals to urinary infections

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It particularly and consistently interacts with the NO-system, in various models and different species (4, 8, 25-27)