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While both glutathione and L-glutathione have similar effects in antioxidant defense, research suggests that L-glutathione supplementation may provide additional benefits

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For eczema patients with suppressed cellular immunity, as evidenced by their susceptibility to viral skin infections like eczema herpeticum, restoring these immune functions could provide meaningful clinical benefit

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According to these authors, the decrease in the amount of GSH was connected with the increase of lipid peroxidation and oxidative stress (Power and Sheehan 1996)