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While short-term, low-dose use may be acceptable for pain management, prolonged NSAID use during the early weeks of fracture healing has been associated with delayed union in some studies

Aquatic Toxicol 101:1330 Belrose JC, Xie YF, Gierszewski LJ, MacDonald JF, Jackson MF (2012) Loss of glutathione homeostasis associated with neuronal senescence facilitates TRPM2 channel activation in cultured hippocampal pyramidal neurons

The researchers further noted that this was mainly composed of fat rather than lean muscle tissue

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Specifically, ACTH and cortisol did not rise above the levels already produced by GHRH alone, and prolactin was likewise unaffected