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Topamax affects neuronal signalling and metabolism, whilst Wegovy primarily influences appetite regulation and glucose homeostasis through hormonal mechanisms

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One key question relates to the extent to which neural circuits that drive appetitive and aversive behaviors are dissociable 68,69

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Rapamycin's interest in longevity protocols involves its action on the mTOR pathway , which researchers have studied in the context of aging processes in animal models and, more recently, in human contexts