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Semaglutide, a type of GLP-1R agonists with 94% sequence homology to GLP-1 and with an extended half-life of approximately 1 week, has been clinically approved to treat T2DM and is available in subcutaneous and oral dosage form (136, 137)

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With the goal of enhancing patient outcomes and enabling practitioners to overcome physician supply shortages, there is an urgent need to explore new pharmacologic therapies that target mechanisms of neuro-ophthalmic degeneration