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Regarding the effect on the expression of TLRs of APCs, this may contribute to an imbalance in the Th17/Treg cell ratio and this local immune response could lead to systemic autoimmunity (Horta-Baas et al., 2017)

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It has been demonstrated that, although MASH drives disease progression, fibrosis is the most critical predictor of prognosis, in terms of both liver disease and overall mortality

Combined with prior Phase Ia/Ib ulcerative colitis data, these results will support a Phase II IND submission to the FDA in 2026

Laboratory animal studies suggest that extended use of ipamorelin might elevate appetite [23]