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In populations of adults with overweight or obesity, use of tirzepatide was associated with significantly greater weight loss than semaglutide [26] [27], suggesting that the superior efficacy observed in controlled trials translates to clinical practice

Poor sleep or conditions like PCOS can slow results

Factors such as your baseline metabolic rate, genetic makeup, underlying insulin resistance, hormonal imbalances, and starting weight all influence how strongly and quickly you respond to GLP-1 medications

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Individual variation is significant based on compliance, starting composition, and metabolic response