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GLP-1 receptor agonists and tirzepatide (a GLP-1/GIP dual agonist) are not formally contraindicated in hypothyroidism, meaning the presence of an underactive thyroid does not automatically disqualify you from these medications

In this multicenter study of over 250,000 hospitalizations, use of novel diabetes medications prior to discharge was rare, raising the concern for systematic underutilization after discharge, Michael Fralick, PhD, MD, MSc, assistant professor in the department of medicine at University of Toronto and clinical scientist at Sinai Health in Toronto, and colleagues wrote

10.1210/endo.139.9.6288

Common Side Effects Explained Although it was originally introduced as a diabetes medication, semaglutide has become an important tool in medically supervised weight loss

Second, the hindbrain GLP-1 neurons are nei- ther directly nor indirectly engaged by systemically administered GLP-1R agonists