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Oxygen supplementation can have a similar stabilizing effect on the ventilatory drive, as increases in the partial pressure of oxygen can lower the bodys peripheral chemosensitivity and downregulate chemical loop gain [82]

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Moreover, the prolonged exposure to amyloid depositions, has also been found to activate microglia, resulting in excessive secretion of synaptic-toxic cytokines, and tau accumulation that eventually cause synaptic loss and neuronal death (Cao et al., 2019)