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On one hand, they are counteracting the SGLT2 inhibitors associated rise in EGP and glucagon, on the other hand, they are potentially applying an additive or synergistic effect on RAAS blocked and glucose-lowering to delay the progression of DKD [17]

Abbreviations AMPK: AMP-activated protein kinase DPP-4: Dipeptidyl peptidase-4 GIP: Glucose-dependent insulinotropic polypeptide GLP-1: Glucagon-like peptide 1 PPAR: Peroxisome proliferator-activated receptor References Nathan DM, Buse JB, Davidson MB et al (2009) Medical management of hyperglycaemia in type 2 diabetes mellitus: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes

Chronic inflammation: Speeds up telomere shortening (a key marker of cellular aging)

Inflammation plays a critical role in cancer cachexia, and BPC157 effectively suppressed the expressions of TNF- and IL-6, both of which are pro-inflammatory cytokines implicated in cachexia