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Chemical Engineering Journal, 316: 951963 Zhou Q, Chen L, Wang Z, Wang J, Ni S, Qiu J, Liu X, Zhang X, Chen X (2017)

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Mechanically, unregulated release of glutamate cannot be effectively buffered or cleared, resulting in impaired glutamate level in extracellular space, which may lead to activation of cell death pathways and secondary injury after acute TBI ( 2 O 2 -induced oxidative stress via increasing superoxide dismutase and glutathione peroxidase activities of bacteria, which may provide new insights of glutamic acid in cellular antioxidant activity ( Pgam5 -/- male mice) after TBI

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This self-limiting mechanism caps IGF-1 LR3 hypertrophic drive at extended exposure, whereas follistatin-344s mechanism (extracellular ligand neutralisation) does not generate equivalent receptor-level feedback