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Novel small molecule inhibitors of nicotinamide N-methyltransferase (NNMT)
References suggest it as a tetrasubstituted variant of the shortest functional GHRH sequence, denoted GRF (1-29)
Because of this, it has gained attention in inflammation research
Loading phases may use higher doses for 4-6 weeks, followed by maintenance therapy
Nevertheless, as the simultaneous activation of GLP-1 and GIP receptors in preclinical models results in greater WL and glucose-lowering efficacy compared to activation of each receptor alone [38,39,40], the interest for the development of unimolecular GLP-1 and GIP RA was increased, despite that this additive effect in food intake and glycaemia was not observed in some acute clinical studies [41, 42]
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