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They added GHK-Cu in concentrations of 10 M to 10 M and measured: Collagen synthesis (by radioactive proline incorporation) Non-collagen protein synthesis Cell proliferation What they found: Stimulation of collagen synthesis by 70 % at the optimal concentration of 10 M (1 nM) The effect was NOT dependent on increased proliferation, fibroblasts increased production per cell Background: GHK without copper had a dramatically weaker effect , Cu is critical Reversibility: After removing GHK-Cu, synthesis returned to baseline Why it matters: This is the fundamental mechanistic study that documented the effect of GHK-Cu on collagen
Glutathione,the mother of all antioxidants, is naturally produced in the liver to mop up free radicals & toxins which causes pre-mature ageing, inflammation, hyperpigmentation & reduced skin functions Reason For Glutathione Supplementation Glutathione levels decrease as we age and thus, the need for supplementation
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Hepatol Int 15:2135 Palma R, Pronio A, Romeo M, Scognamiglio F, Ventriglia L, Ormando VM, Lamazza A, Pontone S, Federico A, Dallio M (2022) The role of insulin resistance in fueling NAFLD pathogenesis: from molecular mechanisms to clinical implications
