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Moreover, GLP-1RA anti-catabolic effects can reduce cartilage degradation through the downregulation of TNF-mediated expression of catabolic enzymes, hence preserving essential components of the extracellular matrix such as type II collagen and aggrecan[15]

Promotion of Satiety By acting on the hypothalamus and other areas of the brain, GLP-1 reduces appetite and promotes feelings of fullness

The 12-week schedule keeps that dose constant while frequency falls: daily in weeks 14, five times weekly in weeks 58, and two or three times weekly in weeks 912

More moderate dose escalation, higher protein targets, mandatory resistance training, and potentially shorter treatment courses with emphasis on maintenance dosing may be appropriate

Data from a total of 7,215 study participants were used