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They are a clinically established treatment for B12 deficiency

Q: How long does it take to feel results from a B12 shot

B12 injections are clinically indicated for patients with confirmed deficiency or malabsorption conditions, including those with pernicious anaemia, gastrectomy, ileal resection, Crohn's disease, or neurological symptoms related to B12 deficiency

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This makes it the practical choice wherever repeated access to a sterile solvent is required